Research Interests

As a bioanalytical chemist, I am interested in using my knowledge of chemistry to design and execute novel methods of measuring living systems. I am particularly interested in the fundamental unit of living systems: individual cells. To measure chemical reactions in individual cells, I am (1) developing molecular tools to measure how cells respond to stress and (2) adapting a specific method of single-cell analysis, termed microfluidic chemical cytometry, for new applications. All of this work is undertaken in collaboration with my undergraduate research students.

Current Projects

  • Design and validation of peptide substrate reporters to measure enzyme activity in cells and cell lysates
  • Capillary electrophoresis-based assays of kinase and peptidase activity
  • Single-cell analysis of oxidative stress response in Dictyostelium discoideum and in Tetrahymena thermophila

For recent updates, visit the Lab Updates page.

Previous Research