As a bioanalytical chemist, I am interested in using my knowledge of chemistry to design and execute novel methods of measuring living systems. I am particularly interested in the fundamental unit of living systems: individual cells. To measure chemical reactions in individual cells, I am (1) developing molecular tools to measure how cells respond to stress and (2) adapting a specific method of single-cell analysis, termed microfluidic chemical cytometry, for new applications. All of this work is undertaken in collaboration with my undergraduate research students.
- Design and validation of peptide substrate reporters to measure enzyme activity in cells and cell lysates
- Capillary electrophoresis-based assays of kinase and peptidase activity
- Single-cell analysis of oxidative stress response in Dictyostelium discoideum and in Tetrahymena thermophila
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